tv fjsr � � hydrochlorothiazide lupus peg chains had little influence on the encapsulation efficiency of methotrexate, but affected the release rate a similar construct between peg chains and ����� was utilized to deliver the anticancer drug fluorouracil encapsulation of fluorouracil into g = ����� dendrimers with carboxymethyl peg surface chains revealed reasonable drug loading, a reduced release rate, and reduced hemolytic toxicity compared to the nonpegylated dendrimer fig etoposide, mefenamic acid diclofenac, and venlafaxine the combination between dendrimers and hydrophilic and or hydrophobic polymer chains has recently been extended to solubilize the hydrophobic anticancer drug etoposide a star polymer composed of amphiphilic block copolymer arms has been synthesized and characterized the core of the star polymer was a hydrochlorothiazide lupus generation two pamamoh dendrimer, the inner block of the arm a lipophilic polyecaprolactone pcl and the outer block hydrochlorothiazide lupus of the arm a hydrophilic peg the starpcl polymer was synthesized first by ringopening polymerization of ecaprolactone with the pamamoh dendrimer as initiator the peg polymer was then attached to the pcl terminus by an esterforming reaction characterization with sec, h nmr, ftir, tga, and dsc confirmed the star structure of the polymers a loading capacity of up to ww was achieved with etoposide a cytotoxicity assay demonstrated that the starpclpeg hydrochlorothiazide lupus copolymer was nontoxic in cell culture citric acidpolyethylene glycolcitric acid cpegc triblock dendrimers generations were applied to encapsulate small molecule drugs such as mefenamic acid and diclofenac the formulations hydrochlorothiazide lupus were stored at room temperature for up to ten months and remained stable with no reported release of the drugs the attachment of the novel thirdgeneration antidepressant venlafaxine onto anionic ����� dendrimers g = via a hydrolyzable ester bond and the incorporation of this drugdendrimer complex into a semiinterpenetrating network of an acrylamide hydrogel has been studied as a novel drug delivery formulation to avoid hydrochlorothiazide lupus the currently necessary multiple daily administration of the antidepressant the effect of peg concentration and molecular weight was studied to find optimal release conditions ibuprofen, indomethacin, nifedipine naproxen, paclitaxel and methylprednisolone the antiinflammatory drug ibuprofen was used as a model compound to study its complexation and encapsulation into generations and ����� dendrimers and a hydrochlorothiazide lupus hyperbranched polyester, having approximately surface ohgroups it was found that up to hydrochlorothiazide lupus ibuprofen molecules were complexed by hydrochlorothiazide lupus the ����� dendrimers through electrostatic interactions between the dendrimer amines and the hydrochlorothiazide lupus carboxyl group of the drug in contrast, up to drug molecules were encapsulated into the hyperbranched polyol the drug was successfully transported into a human lung epithelial carcinoma cells by the dendrimers the ����� dendrimers with either amino or hydroxy surfaces entered the cells faster in approximately hr than the hyperbranched polyol approximately hrs however, both entries were faster than the pure drug the antiinflammatory effect of ibuprofendendrimer complexes was demonstrated by more rapid suppression of cox mrna levels than that achieved by the aleve 12 hour 24 count meijer pure drug the nonsteroidal antiinflammatory drug nsaid indomethacin is practically insoluble in water and only sparingly soluble in alcohol encapsulation of indomethacin into generation ����� dendrimers with amino, hydroxy, hydrochlorothiazide lupus and carboxylate surfaces remarkably enhanced the hydrochlorothiazide lupus drug solubility in water, and therefore, its bioavailability fig the encapsulation efficiency hydrochlorothiazide lupus of indomethacin into ����� dendrimers hydrochlorothiazide lupus is dependent on the dendrimer size g g g g and the surface functionalization, nh peg = pyr hydrochlorothiazide lupus ae fig the effect of ����� hydrochlorothiazide lupus dendrimer generation size and surface functional group on the aqueous solubility, and therefore, bioavailability of the calcium channel blocking agent nifedipine has been studied using ����� dendrimers with eda oi dendrimerconc vw fig molecular structure of indomethacin and its solubility profiles in the presence of differing concentrations of gnhz, ?