paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth inhibition study in nude mice implanted with human colon cancer cells the will flomax slow heartbeat mean tumor volume from each group will flomax slow heartbeat was blotted against the number of days each group involved animals for clarity, error bars were omitted note will flomax slow heartbeat that after weeks the dose, normalized will flomax slow heartbeat for paclitaxel, was tripled in all will flomax slow heartbeat treatment groups empty dqasomes do not will flomax slow heartbeat show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in will flomax slow heartbeat the treatment group, after sacrificing the animals days, later was approximately half of that in all controls although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial will flomax slow heartbeat description in , dqasomes and dqasomelike vesicles have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for will flomax slow heartbeat the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful will flomax slow heartbeat to prof v p torchilin for will flomax slow heartbeat many helpful discussions and for his will flomax slow heartbeat strong and continuous support of my work i also would like to will flomax slow heartbeat sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has will flomax slow heartbeat made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the will flomax slow heartbeat united mitochondrial disease foundation pittsburgh, pa, will flomax slow heartbeat mitovec, inc boston, ma and northeastern will flomax slow heartbeat university boston, ma for the will flomax slow heartbeat financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and will flomax slow heartbeat murphy mp delivery of bioactive molecules to mitochondria in vivo proc natl will flomax slow heartbeat acad sci usa murphy mp and smith ra drug delivery to mitochondria viagra birthday card printable the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev will flomax slow heartbeat szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr will flomax slow heartbeat syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig will flomax slow heartbeat v targeted drug delivery to mammalian mitochondria in living cells exp opin drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting of low molecular weight drugs to mammalian mitochondria drug des rev de rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and will flomax slow heartbeat de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano � and torchilin vp a micellar delivery system for dequalinium � a lipophilic cationic drug with anticarcinoma can remeron improve memory and concentration activity j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers will flomax slow heartbeat rn and turnbull dm gene therapy will flomax slow heartbeat for mitochondrial dna defects is it possible?